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CATEGORIES:Colloquium/Seminar
DESCRIPTION:Flavio Fenton\; School of Physics\; Georgia Tech\n\nApplied Mat
 h for the Heart\; Take a few PDEs and call me in the morning\n\nThe heart i
 s an electro-mechanical system in which\, under normal conditions\, electri
 cal waves propagate in a coordinated manner to initiate an efficient contra
 ction. In pathologic states\, single and multiple rapidly rotating spiral a
 nd scroll waves of electrical activity can appear and generate complex spat
 iotemporal patterns of activation that inhibit contraction and can be letha
 l if untreated. Despite much study\, many questions remain regarding the me
 chanisms that initiate\, perpetuate\, and terminate reentrant waves in card
 iac tissue.In this talk\, we will discuss how we use a combined experimenta
 l\, numerical and theoretical approach to better understand the dynamics of
  cardiac arrhythmias. We will show how mathematical modeling of cardiac cel
 ls simulated in tissue using large scale GPU simulations can give insights 
 on the nonlinear behavior that emerges when the heart is paced too fast lea
 ding to tachycardia\, fibrillation and sudden cardiac death.  Then\, how we
  can use state-of-the-art optical mapping methods with voltage-sensitive fl
 uorescent dyes to actually image the electrical waves and the dynamics from
  simulations in live explanted animal and human hearts (donated from heart 
 failure patients receiving a new heart).  I will present numerical and expe
 rimental data for how period-doubling bifurcations in the heart can arise a
 nd lead to complex spatiotemporal patterns and multistability between singl
 e and multiple spiral waves in two and three dimensions. Then show how cont
 rol algorithms tested in computer simulations can be used in experiments to
  continuously guide the system toward unstable periodic orbits in order to 
 prevent and terminate complex electrical patterns characteristic of arrhyth
 mias.  We will finish by showing how these results can be applied in vitro 
 and in vivo to develop a novel low energy control algorithm that could be u
 sed clinically that requires only 10% of the energy currently used by stand
 ard methods to defibrillate the heart.Overall\, I will present recent advan
 cements in identifying and quantifying chaotic dynamics in the heart\, begi
 nning with mathematical models and extending to experimental validation. Th
 is work demonstrates how applied mathematics enables the development of inn
 ovative methods to control and terminate arrhythmias\, with promising poten
 tial for clinical applications.
DTEND:20251002T222500Z
DTSTAMP:20260305T204935Z
DTSTART:20251002T213500Z
GEO:40.006791;-105.262818
LOCATION:Engineering Center\, ECCR 245
SEQUENCE:0
SUMMARY:Applied Mathematics Department Colloquium - Flavio Fenton
UID:tag:localist.com\,2008:EventInstance_50072313796200
URL:https://calendar.colorado.edu/event/applied-mathematics-department-coll
 oquium-flavio-fenton
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