Title: Daily and Longitudinal Associations Between Medically Motivated Cannabis Use, Anxiety, Pain, and Sleep

Abstract:

The state of Colorado has been on the frontier of cannabis legalization, implementing a medical cannabis program in 2000 and becoming the first state to legalize recreational use in 2012. Over the past decade, access to cannabis throughout the United States has rapidly expanded, with many individuals looking to use cannabis for medically motivated reasons, including anxiety, pain, and sleep. The Center for Health & Neuroscience, Genes & Environment (CUChange) has recently completed the NIH-funded Observational Anxiety Study on Inflammation and Stress (OASIS) and Pain Research: Innovative Strategies with Marijuana (PRISM) studies. These studies assessed longitudinal and acute associations between naturalistic cannabis use on a variety of behavioral outcomes in medically motivated participants. Data presented by Dr. Lisano during this colloquium will focus on analyses, leveraging the daily data collected as part of the OASIS and PRISM projects to assess if there were differences in anxiety, pain, and sleep on days participants used their products compared to days they did not. Additionally, these data explored if these associations differed by cannabis product type (flower vs. edible) or chemovar (THC-dominant, CBD-dominant, or THC+CBD). Dr. Lisano will also discuss potential moderators of these relationships and how lifestyle factors could influence these associations.