Please join Catherine Cook Kaczorowski, associate professor and Evnin Family Endowed Chair in Alzheimer’s, on Friday, Feb. 5, 2021, at 4 p.m. for a virtual IBG First Friday talk, “Multi-Omic Analysis Identifies Drivers Associated with Resilience to Cognitive Aging and Alzheimer’s Dementia”.

Abstract: My laboratories quest to understand the nature of cognitive resilience to normal aging has yielded target pathways for resilience therapies, as well as powerful resources for studying the fundamental mechanisms of resilience to dementia. 1) We developed a proteomics approach to discover new molecules associated with cognitive longevity, and validated Trpc3 as mediator of cognitive aging using gene therapy. 2) We then expanded these approaches to genetically diverse mouse models and identified variants in Dlgap2 that promote resilience to cognitive aging in mice, yielding novel pathways and mechanisms associated with resilience and dementia between mice and humans (See Ouellette et al., 2020). 3) We developed the first translationally relevant mouse model of human late-onset AD (LOAD), the AD-BXDs (Neuner et al., 2019). The AD-BXDs are a set of genetically diverse AD strains that are fully sequenced and reproducible and are an ideal tool for genetic mapping of traits, gene-by-environment interaction tests, and causal inference for discovery of early causal events (Heuer et al., 2020). My talk will focus on this collective work, which includes complete experimental pipelines starting with novel target identification up to experimental validation, demonstrates our ability to develop and implement novel genetic resources for mechanistic and therapeutic discovery in neurodegenerative dementias.  

Please join Catherine Cook Kaczorowski, associate professor and Evnin Family Endowed Chair in Alzheimer’s, on Friday, Feb. 5, 2021, at 4 p.m. for a virtual IBG First Friday talk, “Multi-Omic Analysis Identifies Drivers Associated with Resilience to Cognitive Aging and Alzheimer’s Dementia”.

Abstract: My laboratories quest to understand the nature of cognitive resilience to normal aging has yielded target pathways for resilience therapies, as well as powerful resources for studying the fundamental mechanisms of resilience to dementia. 1) We developed a proteomics approach to discover new molecules associated with cognitive longevity, and validated Trpc3 as mediator of cognitive aging using gene therapy. 2) We then expanded these approaches to genetically diverse mouse models and identified variants in Dlgap2 that promote resilience to cognitive aging in mice, yielding novel pathways and mechanisms associated with resilience and dementia between mice and humans (See Ouellette et al., 2020). 3) We developed the first translationally relevant mouse model of human late-onset AD (LOAD), the AD-BXDs (Neuner et al., 2019). The AD-BXDs are a set of genetically diverse AD strains that are fully sequenced and reproducible and are an ideal tool for genetic mapping of traits, gene-by-environment interaction tests, and causal inference for discovery of early causal events (Heuer et al., 2020). My talk will focus on this collective work, which includes complete experimental pipelines starting with novel target identification up to experimental validation, demonstrates our ability to develop and implement novel genetic resources for mechanistic and therapeutic discovery in neurodegenerative dementias.