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1606 Central Campus Mall, Boulder, CO 80309

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Chemical Approaches to Studying Chromatin 

Numerous studies have highlighted the role epigenetic dysregulation plays disease. In this presentation, I will discuss how modern protein chemistry approaches can be leveraged to study the impact of histone PTMs and mutations on the structure and function of chromatin. In particular, I will focus on the development of new chemical biology methods for interrogating how histone marks and mutations alter the interactome of chromatin and how these perturbations affect biochemical processes that act on the polymer. 

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